Upcoming Conferences

September 28, 2026
C3's Second Annual CF Day - Register Today
​Time: 8:00 AM to 3:30 PM
Location: Stecker Auditorium at Nationwide Children's Hospital
September 29, 2026
C3's Annual Board Meeting - Registration Information To Come
​Time: 8:00 AM to 3:30 PM
Location: Stecker Auditorium at Nationwide Children's Hospital

Highlighted Achievements 

July 1, 2026
Jay Freeman, MD, was awarded an NIH/NIDDK R01 grant to fund the PAUSE Study, evaluating whether pancreatic enzyme replacement therapy can reduce pancreatitis episodes in children with pancreatic sufficient acute recurrent and chronic pancreatitis.
July 1, 2026
Ben Kopp, MD, was awarded a CFF grant for his study, CFTR modulator impacts on inflammation in the gut-lung axis.
July 1, 2026
Rosara Bass, MD, received funding from CFF for her study, Body Surface Gastric Mapping in CF.
July 1, 2026
Claire Gwilt, MD, received a CF Educational and Training Clinical Fellowship grant from CFF.
April 13, 2026
Karen McCoy, MD, Sriram Vaidyanathan, PhD, Susan Reynolds, PhD, Tendy Chiang, MD, and Mark Peeples, PhD were featured in Pediatrics Nationwide article Beyond Modulators: Ensuring All Patients With Cystic Fibrosis Benefit From the Next Wave of Therapy.
March 30, 2026
Sriram Vaidyanathan, PhD featured in Pediatrics Nationwide article Genome Database Analysis Suggests Cystic Fibrosis is More Globally Distributed Than Previously Believed
March 2, 2026
Benjamin Kopp's lab moved back to Nationwide Children's Hospital, bringing CFF and NIH funded projects.
February 19, 2026
Dan Wozniak's group in collaboration with scientists at University of Washington secures NIH funding to study early events of Pseudomonas aeruginosa colonization.
November 2025
Mark Peeples, Estelle Cormet-Boyaka, and Susan Reynolds of the EPAIC received a two-year grant from the CF Foundation titled "Development of Human Lung Model Platforms for Future Gene Therapy Testing" 
October 17, 2024
Student-led thrift sale raises awareness for cystic fibrosis.
Breathe Hope, a student organization at The Ohio State University, recently hosted its second thrift sale to raise awareness and funds for cystic fibrosis research.
October 9, 2024
Mark Mitton-Fry receives 2024 Falk Medical Research Trust Catalyst Award.
May 17, 2024
News from Dan Wozniak's lab: Sarah MacDowell, MD received a CF Clinical Fellowship grant from CFF focusing on Innovative Models of Bacteriophage Therapy Targeting Pseudomonas in Cystic Fibrosis. 
March 22, 2024
Amal Amer, MD, PhD, professor of microbial infection and immunity in the College of Medicine, has earned The Ohio State University 2024 Distinguished Scholar Award.

Recent Publications

July 2026
Study Design Considerations for the Evaluation of Pancreatic Enzyme Replacement Therapy (PERT) Products in People with Cystic Fibrosis: An Update
Konstan MW, Ramsey ML, Sathe M, Freeman AJ, Freedman SD, Schwarzenberg SJ, O'Rourke C, Onchiri FM, Setiawan L, Pilewski JM, Mayer-Hamblett N.
Published in the Journal of Clinical Therapeutics. PMID: 42150996. 
June 2026
A Chimeric Airway Model Enables Evaluation of Essential Genes In Vivo
Calyeca J, Liu L, Li K, Drake K, Najibi H, Dharmadhikari S, Carraro G, Reynolds SD, Stripp BR, Chiang T.
Published in the Journal of Respiratory Cell and Molecular Biology. PMID: 42301704. 
June 2026
Protocol to quantify desmoglein 3 tension at cell-cell adhesions using FRET-based tension sensors
Safa BT, Goldsmith T, Kezhaya Z, Seman S, Conway DE, Yang R
Published in STAR Protocols. PMID: 42301820. 
June 2026
A humanized monoclonal antibody potentiates killing of Pseudomonas aeruginosa by common antibiotics
Rhodes JD, Goodman SD, Bakaletz LO
Published in the Journal of Global Antimicrobial Resistance. PMID: 41932437. 
June 2026
CRISPRi screening identifies SON and MAP4K1 as regulators of type III cytokine expression in innate lymphoid cells
Brown RA, Dangel AW, Saini A, Collins PL, Colonna M, Oltz EM
Published in the Journal of Immunology. PMID: 42267671. 
June 2026
Pathologic wall shear stress in the trachea decreases epithelial differentiation and increases fibrosis
Dharmadhikari S, Calyeca J, Liu L, Wu Z, Schneller A, Hussein Z, Tan ZH, Breuer CK, Reynolds SD, Zhao K, Chiang T
Published in the American Journal of Respiratory Cell and Molecular Biology. PMID: 41738144. 
June 2026
Dual host and pathogen targeting by MEK1/2 inhibitors
Zuiker E, Long ME
Published in the Journal of Infection and Immunity. PMID: 42240383. 
June 2026
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC); INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE). Long-term disease progression in pediatric acute recurrent and chronic pancreatitis: A report from INSPPIRE.
Downs EM, Perito ER, Wang F, Cress GA, Abu-El-Haija M, Chugh A, Cohen RZ, Fishman DS, Freeman AJ, Gariepy CE, Giefer MJ, Gonska TY, Grover AS, Husain SZ, Lindblad D, Liu QY, Maqbool A, Mark JA, McFerron BA, Mehta MS, Morinville VD, Ng K, Noel RA, Ooi CY, Troendle DM, Wilschanski M, Zheng Y, Yuan Y, Lowe ME, Uc A
Published in the Journal of Pancreatology. PMID: 41672858. 
May 2026
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). Pancreatitis Risk Genes Play a Major Role in Pediatric Pancreatitis: Insights From INSPPIRE
Abu-El-Haija M, Zhang W, Wang F, Cress G, Dawson B, Su X, Thompson T, Kotha N, Chugh A, Cohen RZ, Downs EM, Fishman DS, Freeman AJ, Gariepy CE, Giefer MJ, Gonska TY, Greer P, Grover AS, Liman AYJ, Lindblad D, Liu QY, Maqbool A, Mark JA, McFerron BA, Mehta MS, Morinville VD, Ng K, Noel RA, Ooi CY, Perito ER, Wilschanski M, Zheng Y, Yuan Y, Whitcomb DC, Uc A, Lowe M
Published in the Journal of Clinical Gastroenterology Hepatology. PMID: 42303027. 
May 2026
Exocrine Pancreatic Insufficiency
Ramsey ML, Forsmark CE
Published in JAMA. PMID: 4226862. 
June 2026
Cystic Fibrosis-Asthma Overlap Syndrome: Current Understanding and Future Directions
Miralda I, Aridgides DS, Ozuna H, Britt RD Jr, Kopp BT
Published in Pediatric Pulmonology. PMID: 42252942.. 
May 2026
A rapid yeast-based reverse genetics system reveals SARS-CoV-2 Omicron BA.2.86 variant spreads faster than Omicron JN.1 variant in primary human nasal and bronchial epithelial airway cultures
Xu J, Chamblee M, Hsu CC, Jiang F, Chen P, Zhang Y, Liang X, Amer AO, Boyaka PN, Cormet-Boyaka E, Peeples ME, Li J
Published in mBio. PMID: 42112831. 
May 2026
Pseudomonas aeruginosa biofilm-deficient mutants undergo parallel evolution during chronic infection
Gloag ES, Marshall CW, Kubota N, Deaver SE, Deshotel B, Cooper VS, Wozniak DJ
Published in the Journal of Bacteriology. PMID: 42207692. 
May 2026
Cadmium inhibits hSMUG1-mediated uracil excision: quantitative analysis and mitigation by Ganoderma lucidum extracts
Chang HL, Fang CH, Chang HL, Lee YF, Hsu WL, Chang JH, Chien MH, Goodman SD, Chang SY, Fang WH, Su KY
Published in the Journal of Enzyme Inhibition and Medicinal Chemistry. PMID: 42117622. 
May 2026
Spermidine is a common component of the eDNA-dependent biofilm matrix
More KR, Buzzo JR, Devaraj A, Balu S, Bakaletz LO, Goodman SD
Published in NPJ Biofilms and Microbiomes. PMID: 42120400. 
May 2026
Biomaterial Selection Regulates Tissue Remodeling and Collagen Deposition in Composite Tracheal Grafts
Chan O, Calyeca J, Hussein Z, Liu L, Dharmadhikari S, Li K, Johnson J, Chiang T
Published in JAMA Otolaryngology-Head and Neck Surgery. PMID: 42171329. 
May 2026
An update on cystic fibrosis Hepato-biliary involvement
Freeman AJ, Bodewes FAJA.
Published in the Journal of Cystic Fibrosis. PMID: 41963204. 
May 2026
Updates on pancreas exocrine function in cystic fibrosis for the era of highly effective modulator therapy
Ramsey ML, Ooi CY
Published in the Journal of Cystic Fibrosis. PMID: 41887977. 
May 2026
CFTR modulators reduce acute pancreatitis episodes in individuals with CFTR-related disorders: A case series
Ramsey ML, Corzo M, Bass R, Lara LF, Hart PA, Freeman AJ
Published in the Journal of Cystic Fibrosis. PMID: 41580354. 
May 2026
Maldigestion, dysbiosis, inflammation and dysmotility: a toxic tetrad in the CF gut
Bass R, Smyth AR
Published in the Journal of Cystic Fibrosis. PMID: 42223231. 
April 2026
Staphylococcus aureus biofilm extracellular DNA neutralizes the antimicrobial activity of histone H3
Rana PSJB, Foley JR, Bhattacharya M, Gloag ES, Wozniak DJ
Published in NPJ Biofilms and Microbiomes. PMID: 41974738. 
April 2026
Cystic Fibrosis-Related Diabetes: Pathophysiology, Spectrum of Glycemic Abnormalities, and Evolving Approaches to Screening
Gandhi K, Perdomo Rodriguez JP, Bianco ME, Bartz SK, Chan CL
Published in Endocrine Practice. PMID: 42066845. 
April 2026
A Precious Child's Legacy: Insights Into Advanced Lung and Liver Disease in Children With Cystic Fibrosis
Paul GR, Lakhani A, McCoy KS, Jay Freeman A
Published in Pediatric Pulmonology. PMID: 41928623. 
April 2026
Highly Effective Modulator Therapies Restore Neutrophil Dysfunction in People with Cystic Fibrosis
Robledo-Avila FH, Rascon R, Montanez-Barragan A, Loyo-Celis V, Singh H, Mccoy KS, Kopp BT, Partida-Sánchez S
Published in the American Journal of Respiratory Cell and Molecular Biology. PMID: 42089325.
April 2026
Maternal and perinatal nutritional programming of lung health and disease in childhood and early adulthood: Research gaps and opportunities-National Heart, Lung, and Blood Institute/National Institutes of Health Workshop Report
McEvoy CT, Idrose NS, Dharmage SC, Bui DS, Simpson SJ, Patchen B, Marshall NE, Kelly RS, Lynch SV, McDonald CM, Sood BG, Pratt C, Vitalis D, Lu Q, Carroll KN, Duijts L, Forno E, Venter C, Prakash YS, Miller AN, DeMeo DL, Subbarao P, Britt RD Jr, Sengupta S, McGrath-Morrow SA, Litonjua AA
Published in the Journal of Allergy and Clinical Immunology. PMID: 42061466.
March 2026
Challenges and Practical Solutions in the Management of Cystic Fibrosis in Resource-Limited Countries: The Indian Experience 
Paul GR, Varkki SD, Kabra SK
Published in Pediatric Pulmonology. PMID: 41757536
January 2026
Feeding the invaders: how metabolic imbalance shapes infection and biofilm development
Mahajan S, MacDowell S, Mitchem C, Alexander E, Wozniak DJ
Published in FEMS Microbiology. PMID: 42377912

Core Services

C3 is organized around three biomedical research cores that support ongoing research projects.

Grant Opportunities

C3 Training Grant Award:
Grant Application Deadline: 
Closed
C3 Pilot & Feasibility Award:
Grant Application Deadline: 
Closed

Our Research

C3 researchers have many exciting collaborative projects aimed at understanding the interplay of host immunity, infection, and inflammation in persons with CF.

Karen McCoy, MD​

Program Co-Director
​Nationwide Children's Hospital
Email

Daniel Wozniak, PhD​

Program Co-Director
​The Ohio State University
Email

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