Upcoming Conferences

September 28, 2026
C3's Second Annual CF Day - Click to view: 2025 Agenda
​Time: 8:00 AM to 4:00 PM
Location: Stecker Auditorium at Nationwide Children's Hospital

Highlighted Achievements 

April 10, 2026
Pranav Rana, postdoctoral scientist in Wozniak lab publishes new paper on Staphylococcus aureus interactions with neutrophil-derived histones in npj Biofilms and Microbiomes
March 30, 2026
Sriram Vaidyanathan, PhD featured in Pediatrics Nationwide article Genome Database Analysis Suggests Cystic Fibrosis is More Globally Distributed Than Previously Believed
February 19, 2026
Dan Wozniak's group in collaboration with scientists at University of Washington secures NIH funding to study early events of Pseudomonas aeruginosa colonization.
October 17, 2024
Student-led thrift sale raises awareness for cystic fibrosis.
Breathe Hope, a student organization at The Ohio State University, recently hosted its second thrift sale to raise awareness and funds for cystic fibrosis research.
October 9, 2024
Mark Mitton-Fry receives 2024 Falk Medical Research Trust Catalyst Award.
May 17, 2024
News from Dan Wozniak's lab: Sarah MacDowell, MD received a CF Clinical Fellowship grant from CFF focusing on Innovative Models of Bacteriophage Therapy Targeting Pseudomonas in Cystic Fibrosis. 
March 22, 2024
Amal Amer, MD, PhD, professor of microbial infection and immunity in the College of Medicine, has earned The Ohio State University 2024 Distinguished Scholar Award.

Highlighted Publications

January 3, 2024
A bacterial pigment provides cross-species protection from H2O2- and neutrophil-mediated killing
Yiwei Liu, Eleanor A. McQuillenc, Pranav S. J. B. Rana, Erin S. Gloag, Matthew R. Parseke, Daniel J. Wozniak
Published in The Proceedings of the National Academy of Sciences (PNAS). PMID: 38170744
November 25, 2023
Disruption of nontuberculous mycobacteria biofilms induces a highly vulnerable to antibiotic killing phenotype
Nikola Kurbatfinski, Preston J Hill, Noah Tobin, Cameron N Kramer, Joseph Wickham, Steven D Goodman, Luanne Hall-Stoodley, Lauren O Bakaletz
Published in The Biofilm Journal. PMID: 38078059
November 3, 2023
DNA strand breaks and gaps target retroviral intasome binding and integration
Gayan Senavirathne, James London, Anne Gardner, Richard Fishel, Kristine E Yoder
Published in The Nature Communications. PMID: 37923737
June 15, 2023
Optimization of Phage-Antibiotic Combinations against Staphylococcus aureus Biofilms
Razieh Kebriaei, Susan M Lehman, Rahi M Shah, Kyle C Stamper, Ashlan J Kunz Coyne, Dana Holger, Amer El Ghali, Michael J Rybak
Published in the Microbiology Spectrum Journal. PMID: 37199616
April 1, 2023
Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor
Shuzhong Zhang, Chandra L. Shrestha, Frank Robledo-Avila, Devi Jaganathan, Benjamin L. Wisniewski, Nevian Brown, Hanh Pham, Katherine Carey, Amal O. Amer, Luanne Hall-Stoodley, Karen S. McCoy, Shasha Bai, Santiago Partida-Sanchez, Benjamin T. Kopp
Published in The European Respiratory Journal. PMID: 36265882
March 2023
Impact of elexacaftor-tezacaftor-ivacaftor on bacterial colonization and inflammatory responses in cystic fibrosis
Shahid Sheikh, Rodney D Britt Jr, Nancy A Ryan-Wenger, Aiman Q Khan, Brandon W Lewis, Courtney Gushue, Hazel Ozuna, Devi Jaganathan, Karen McCoy, Benjamin T Kopp
Published in The Journal of Pediatric Pulmonology. PMID: 36444736
December 21, 2022
Surface Dependent Inhibition of Mycobacterium abscessus by Diverse Pseudomonas aeruginosa Strains
Ayantu W Idosa, Daniel J Wozniak, Luanne Hall-Stoodley
Published in The Microbiology Spectrum Journal. PMID: 36394312
July 12, 2022
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease
Susan D. Reynolds, Cynthia L. Hill, Alfahdah Alsudayri, Scott W. Lallier, Saranga Wijeratne, Zheng Hong Tan, Tendy Chiang, Estelle Cormet-Boyaka
Published in The JCI Insight. PMID: 35819850
June 22, 2022
Tissue-localized immune responses in people with cystic fibrosis and respiratory nontuberculous mycobacteria infection
Don Hayes Jr, Rajni Kant Shukla, Yizi Cheng, Emrah Gecili, Marlena R Merling, Rhonda D Szczesniak, Assem G Ziady, Jason C Woods, Luanne Hall-Stoodley, Namal Pm Liyanage, Richard T Robinson
Published in JCI Insight. PMID: 35536650
May 2022
Targeting the EGFR-ERK axis using the compatible solute ectoine to stabilize CFTR mutant F508del
Jack Wellmerling, Rachael E Rayner, Sheng-Wei Chang, Elizabeth L Kairis, Sun Hee Kim, Amit Sharma, Prosper N Boyaka, Estelle Cormet-Boyaka
Published in The FASEB Journal. PMID: 35412656
February 16, 2022
CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages
Asmaa Badr, Mostafa Eltobgy, Kathrin Krause, Kaitlin Hamilton, Shady Estfanous, Kylene P Daily, Arwa Abu Khweek, Ahmad Hegazi, Midhun N K Anne, Cierra Carafice, Frank Robledo-Avila, Youssra Saqr, Xiaoli Zhang, Tracey L Bonfield, Mikhail A Gavrilin, Santiago Partida-Sanchez, Stephanie Seveau, Estelle Cormet-Boyaka0, Amal O Amer
Published in Frontiers in Cellular and Infection Microbiology. PMID: 35252032
December 2021
Repeated injury promotes tracheobronchial tissue stem cell attrition
Moumita Ghosh, Cynthia L Hill, Alfahdah Alsudayri, Scott W Lallier, Don Hayes Jr, Saranga Wijeratne, Zhang Hong Tan, Tendy Chiang, John E Mahoney, Gianni Carraro, Barry R Stripp, Susan D Reynolds 
Published in The STEM CELLS Translational Medicine Journal. PMID: 34546001
November 15, 2021
Elexacaftor/Tezacaftor/Ivacaftor Improved Clinical Outcomes in a Patient with N1303K-CFTR Based on In Vitro Experimental Evidence
Yunjie Huang, Grace Paul, Jesun Lee, Sunitha Yarlagadda, Karen McCoy, Anjaparavanda P Naren
Published in The American Journal of Respiratory and Critical Care Medicine. PMID: 34379998
November 11, 2021
Z-form extracellular DNA is a structural component of the bacterial biofilm matrix
John R Buzzo, Aishwarya Devaraj, Erin S Gloag, Joseph A Jurcisek, Frank Robledo-Avila, Theresa Kesler, Kathryn Wilbanks, Lauren Mashburn-Warren, Sabarathnam Balu, Joseph Wickham, Laura A Novotny, Paul Stoodley, Lauren O Bakaletz, Steven D Goodman
Published in The Cell Press. PMID: 34735796
October 28, 2021
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA
Yanran Lu, Sandip Vibhute, Linsen Li, Antony Okumu, Steven C. Ratigan, Sheri Nolan, Jonathan L. Papa, Chelsea A. Mann, Anthony English, Anna Chen, Justin T. Seffernick, Bryan Koci, Leonard R. Duncan, Brieanna Roth, Jason E. Cummings, Richard A. Slayden, Steffen Lindert, Craig A. McElroy, Daniel J. Wozniak, Jack Yalowich, Mark J. Mitton-Fry
Published in The Journal Medicinal Chemistry. PMID: 34614347
July 2021
Defective immunometabolism pathways in cystic fibrosis macrophages
Kaitlin Hamilton, Kathrin Krause, Asmaa Badr, Kylene Daily, Shady Estfanous, Mostafa Eltobgy, Arwa Abu Khweek, Midhun N K Anne, Cierra Carafice, Daniel Baetzhold, Jeffrey R Tonniges, Xiaoli Zhang, Mikhail A Gavrilin, Narasimham L Parinandi, Amal O Amer
Published in The Journal of Cystic Fibrosis. PMID: 33208300
March 3, 2021
Mycobacterium abscessus biofilms have viscoelastic properties which may contribute to their recalcitrance in chronic pulmonary infections
Erin S Gloag, Daniel J Wozniak, Paul Stoodley, Luanne Hall-Stoodley
Published in The Scientific Reports. PMID: 33658597
February 23, 2021
Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies
Laura K Jennings, Julia E Dreifus, Courtney Reichhardt, Kelly M Storek, Patrick R Secor, Daniel J Wozniak, Katherine B Hisert, Matthew R Parsek
Published in Cell Reports. PMID: 33626358
January 2021
Airway epithelial stem cell chimerism in cystic fibrosis lung transplant recipients
Don Hayes Jr, Rachael E Rayner, Cynthia L Hill, Alfahdah Alsudayri, Mahelet Tadesse, Scott W Lallier, Hemant Parekh, Guy N Brock, Estelle Cormet-Boyaka, Susan D Reynolds
Published in The Journal of Cystic Fibrosis. PMID: 33187933
September 2020
In vitro 3D culture lung model from expanded primary cystic fibrosis human airway cells
Rachael E Rayner, Jack Wellmerling, Wissam Osman, Sean Honesty, Maria Alfaro, Mark E Peeples, Estelle Cormet-Boyaka
Published in The Journal of Cystic Fibrosis. PMID: 32565193
June 16, 2020
Advanced Live Attenuated Vaccines for the Prevention of Respiratory Syncytial Virus Infections in Young Children
Octavio Ramilo, Rosa Rodriguez-Fernandez, Mark E Peeples, Asuncion Mejias
Published in The Journal of Infectious Diseases. PMID: 31549154
May 28, 2020
Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial
Harry G M Heijerman, Edward F McKone, Damian G Downey, Eva Van Braeckel, Steven M Rowe, Elizabeth Tullis, Marcus A Mall, John J Welter,
Bonnie W Ramsey, Charlotte M McKee, Gautham Marigowda, Samuel M Moskowitz, David Waltz, Patrick R Sosnay, Christopher Simard,
Neil Ahluwalia, Fengjuan Xuan, Yaohua Zhang, Jennifer L Taylor-Cousar, Karen S McCoy, on behalf of the VX17-445-103 Trial Group†
Published in The Lancet. PMID: 31679946
March 2020
Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis
Benjamin T Kopp, James Fitch, Lisa Jaramillo, Chandra L Shrestha, Frank Robledo-Avila, Shuzhong Zhang, Sabrina Palacios, Fred Woodley, Don Hayes Jr, Santiago Partida-Sanchez, Octavio Ramilo, Peter White, Asuncion Mejias
Published in The Journal of Cystis Fibrosis. PMID: 31474496
December 5, 2019
Caspase-11 counteracts mitochondrial ROS-mediated clearance of ​Staphylococcus aureus in macrophages
Kathrin Krause, Kylene Daily, Shady Estfanous, Kaitlin Hamilton, Asmaa Badr, Arwa Abu Khweek, Rana Hegazi, Midhun Nk Anne, Brett Klamer, Xiaoli Zhang, Mikhail A Gavrilin, Vijay Pancholi, Amal O Amer
Published in The EMBO Reports. PMID: 31637841
November 2019
Mucoid Pseudomonas aeruginosa and regional inflammation in the cystic fibrosis lung
Sankalp Malhotra, Don Hayes Jr, Daniel J Wozniak
Published in The Journal of Cystic Fibrosis. PMID: 31036488

Core Services

C3 is organized around three biomedical research cores that support ongoing research projects.

Grant Opportunities

C3 Training Grant Award:
Grant Application Deadline: 
Closed
C3 Pilot & Feasibility Award:
Grant Application Deadline: 
Closed

Our Research

C3 researchers have many exciting collaborative projects aimed at understanding the interplay of host immunity, infection, and inflammation in persons with CF.

Karen McCoy, MD​

Program Co-Director
​Nationwide Children's Hospital
Email

Daniel Wozniak, PhD​

Program Co-Director
​The Ohio State University
Email

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