Persons with CF are prone to chronic infections and hyperinflammatory responses, which are associated with progressive tissue damage. It is now recognized that chronic infection and inflammation results from intrinsically dysfunctional immune cells. Therefore, the overarching goals of the Immune Core are to provide a unified source of fresh immune cells to investigators, deliver reproducible data, and enable training of students and fellows in CF immune cell functions. The Immune Core services support projects and C3 members who seek to understand complex CF host-pathogen interactions and inflammation and thereby develop novel therapeutic strategies that prevent the establishment of chronic infections and tissue destruction.
Facilitates Research Through: